The interactions between cannabinoids and the human organism are far from being fully understood. However, research and the experience of many users suggest that the cannabinoid may have sedative, anti-inflammatory, anxiolytic and pain-relieving effects.
Because of the presumed positive properties, researchers are currently testing variants of the oil for sleep disorders. Furthermore, there is a significant antioxidant effect and a connection with the immune system.
The main mechanisms of action of cannabidiol
Natural painkiller:The so-called vanilloid receptors at the nerve endings play a decisive role in the perception of pain. Cannabidiol seems to dock to the vanilloid receptors of type 1 and type 2 just like the ingredients of the vanilla plant.Furthermore, animal studies suggest that CBD may also induce a pain-inhibiting mechanism via glycine receptors, particularly in chronic pain.
Anti-inflammatory effect:scientists have already found some evidence that the cannabinoid has an anti-inflammatory effect. Currently, it is assumed that it can enhance the signaling effect of adenosine. This may be the basis for some of the anti-inflammatory mechanisms of action.An arthritis study also suggests that its use may inhibit the inflammatory processes responsible for the disease and relieve pain. It can be assumed that the effects could be transferable to other inflammatory processes.
Calming, relaxing and anxiety-relieving:Among the most researched effects is the calming, relaxing and anxiety-relieving effect. Several studies seem to be coming to a conclusion. One of them was a study that examined cannabidiol as a potential drug for anxiety disorders.Researchers at the University of Milan also suspect an anxiety-reducing and anti-psychotic influence.
Strengthening for the immune system: It issaid that taking the full-spectrum hemp drops is supposed to strengthen the immune system. The background is probably not only the cannabinoid itself, but also the large number of micronutrients it contains. These include chlorophyll and carotenoids as well as vitamins E, B1 and B12.Overall, the cocktail is said to support the fight against harmful free radicals and at the same time prevent oxidative cell damage. Large-scale studies to prove this are currently still pending.
How fast does it work?
The occurrence of the first effects after consumption depends on several factors. Experience shows that some users notice the first signs of this shortly afterwards. In others, it takes several weeks before the body shows a clear reaction to the substance. Since every organism is unique, cannabinoids act at different rates in different people.
The first decisive factor is the dosage form.
The route by which the active substance enters the body determines the absorption time. By this we mean the time span until the substance is completely absorbed into the blood. While it can take a good 20 minutes to 2 hours for external absorption through the skin, the first effects are often immediately noticeable when e-liquids are vaporized.
During vaporization, the active ingredient enters the bloodstream directly via the alveoli. Active agents from creams on the other hand have to work their way through the skin first.
It is quicker with capsules that dissolve in the stomach and release their active ingredients into the blood after a good hour. The effect of the oil, which is dropped under the tongue, takes effect after only 15-20 minutes. Responsible is the partial absorption through the oral mucosa.
There are other factors as well:
Quality of the oil: The higher the quality, the better the bioavailability. Products with good bioavailability can be absorbed by the organism faster and more efficiently.
Dosage: For the cannabinoid to have an effect, a minimum amount must be present. Only in this way can a sufficient number of molecules occupy the cannabinoid receptors and trigger the desired effects.
Concentration of the oil: Here the same rule applies as for the dosage - the more active ingredient enters the organism at the same time, the faster possible effects occur. A small amount of a high dosage oil can act faster than a large amount of a low dosage oil.
Messenger substance situation in the body:If the organism is not receptive, cannabinoids can only act slowly or not at all. This is for example the case when many cannabinoid receptors are already blocked by other molecules.
Tip: According to our experience, cannabidiol oils unfold their effect most quickly on an empty stomach.
How long does CBD work?
After application, the active ingredient remains in the body for several hours. Exactly for how long depends on the dosage, bioavailability and dosage form, as does the initial onset of action.
But also the metabolic state, the lifestyle of the user, the body weight and the habituation to cannabinoids are decisive. Experience shows that the effect lasts for about 4 to 6 hours on average. In individual cases, deviations both upwards and downwards are possible.
As a rule of thumb:If cannabidiol enters the circulation quickly (e.g. by smoking or vaporization) the half-life is shorter. If absorption is slower (e.g. via the stomach or skin), the effect will last longer.
Drug test - can I drive?
In general, the cannabinoid is detectable in the body for longer than the effects themselves last. Depending on the individual, this can be up to five days. You don't have to be afraid of a drug test, though.
Finally, cannabidiol is neither psychoactive nor prohibited.In addition, drug tests do not check for CBD consumption either as part of traffic controls or during company medical examinations.In the case of professionally produced oils that do not exceed the limit value of 0.2% THC, a drug test is not expected to be positive either. With such small amounts, you would have to overdose a legal product heavily to even come close to the legal limit of 1 mg/ml for tetrahydrocannabinol. Driving is therefore allowed.
Warning:A study shows that people who regularly consume tetrahydrocannabinol products may experience interactions. The combination with cannabidiol products could lead to increased THC levels in the blood.