How does CBD affect the endocannabinoid system?

How does CBD affect the endocannabinoid system?

While trying to develop an understanding of the effects of cannabis on humans, scientists discovered the endocannabinoid system in the human body.

Little is still known about this, but science now knows that humans have many cannabinoid receptorsand also produce corresponding molecules. These in turn are responsible for the physical and also physiological effects of cannabis on the body.

The fact that cannabis is effective on the body is due to the endocannabinoid system, which has become a real "object of research" in medicine since its discovery.

The endocannabinoid system - what is it actually?

The endocannabinoid system is a network of receptors that reach all those parts of the body that are also reached by the central nervous system. The name already suggests it: The cannabinoids in cannabis interact with the endocannabinoid system.

It is assumed that this system takes over a multitude of functions within the human organism - it is supposed to be able to influence the immune system or inflammatory processes. The receptors in the endocannabinoid system cause effects that are not only characterized by "being high".

Functions of the endocannabinoid system

The endocannabinoid system can influence the immune system and inflammatory processes as well as the following functions of the human body:

  • appetite and digestion
  • the atmosphere
  • the sleep
  • the metabolism
  • the memory
  • neuroprotection and development
  • the reproduction

Cannabinoid receptors are found throughout the body. A large number of CB1 receptors are found in the central nervous system, while CB2 receptors are localized in immune cells as well as in the gastrointestinal tract and peripheral nervous system.

What are endocannabinoids?

An endocannabinoid is a cannabinoid that is naturally produced in the human body. Ennocannabinoids are formed within body fatty acids such as omega-3

Endocannabinoids are produced in the body so that they can trigger essential functions. Scientists assume that too low cannabinoid levels could be responsible for certain diseases (e.g. chronic pain, fibromyalgia).

Endocannabinoids are classified as follows:


Anandamide is the first endocannabinoid discovered by scientists, which is called "Ananda" ("bliss") in Sanskrit. In higher concentrations it is found in body regions that are further away from the brain.

2-AG (2-eachidonoylglycerol)

These endocannabinoids are "short-term" neurotransmitters that are only synthesized when they are acutely needed by the body. After their release they are broken down by the enzymes FAAH and MAGL (fatty acid amide hydrolase and monoacylglycerol lipase).

Other endocannabinoids

In addition to the two important endocannabinoids mentioned above, there are other substances whose role in the human body has not yet been fully identified. These include NADA (N-arachidonoyldopamine), noladinether and virodhamine.

What are cannabinoids?

Cannabinoids are natural chemical messengers that are present in the body in large numbers as endogenous and exogenous cannabinoids.

Endogenous cannabinoids have their origin in the body, they are produced by the human organism and interact directly with cannabinoid receptors. This regulates various basic functions.

Exogenous cannabinoids are therefore located outside the body and are found mainly in cannabis in the form of THC (tetrahydrocannabinol) and CBD (cannabidiol). When using these cannabinoids, they also interact with the endocannabinoid system, but produce physical and also psychological effects.


Cannabidiol does not bind to receptors but acts as an inhibitor of the enzyme FAAH. This slows down or even prevents the breakdown of anandamide, which in turn builds up the substance in the brain.

The cannabinoid most likely has an effect on the physiological level and is now being investigated in medicine for severe diseases such as tumours, epilepsy or cardiovascular diseases. It is also used in rheumatoid arthritis, diabetes, inflammatory processes, psychosis and anxiety disorders, as well as severe muscle cramps and neuropathic pain.


The effect of THC is mainly based on psychological mechanisms. But it is not only a frenzy that is caused. It has also been proven that THC can also be helpful in chronic pain, nausea, loss of appetite, asthma and glaucoma.

It has also been proven to be tested and convincing in cancer treatment, provided it is used in combination with CBD.

What role does cannabidiol play in the endocannabinoid system?

The main types of receptors in the endocannabinoid system are - as already mentioned - CB1 and CB2. Cannabidiol cannot bind to either receptor, so stimulation occurs directly in the cells in which the receptors are activated. There is no blockage.

Cannabidiol is transported through the bloodstream, while in the organism it can lead to interactions with far-reaching effects. This is because the endocannabinoid receptors are distributed throughout the body.

Scientists and doctors are very interested in the endocannabinoid system. The complex system in the human body plays an important role in various functions. The system can be effectively achieved with the help of medical cannabis, which is why exogenous cannabinoids are now more commonly found in drugs and are prescribed as medicine worldwide.

Cannabidiol does not only stimulate the endocannabinoid system. Thus, it should also contribute to the activation of serotonin receptors and the stimulation of G-protein coupled receptors. This influences temperature control and pain perception. Cannabidiol is considered to be a very complex cannabinoid that works with the whole body.

Note: In this article we report on prescription cannabis, prescription CBD or over-the-counter or legal CBD. This Article does not make any proposal as to the possible purpose of the proposal and is for information and education purposes only. Promises of healing and benefits are excluded.